Effects of Human Nucleolus Upon Guest Viral-Life, Focusing in COVID-19 Infection: A Mini- ReviewReview Article Published on 2022-12-152022-10-29 Journal: Iranian Journal of Pathology [Category] COVID-19, [키워드] accumulating biogenesis Cell cell stress concerning coronavirus disease Coronavirus infections COVID-19 DDR disrupt DNA damage Effect endotheliopathy eukaryotic cells Evidence Focusing function gene silencing Human human diseases MINI nucleoli Nucleolopathy Nucleolus nucleus organism Organisms pathogenic precursor Protein provided Regulation Replication review subcellular tRNA viral infection viral infections virus [DOI] 10.30699/IJP.2021.540305.2744 PMC 바로가기 [Article Type] Review Article
Impaired immune response drives age-dependent severity of COVID-19Article Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 치료제, [키워드] Adaptive immune response Aggravated Antiviral benefit caused characterized combinatorial treatment correlation COVID-19 disease disease severity function IFN IFN-γ IFN-λ immune response Immunity Immunotherapy Impaired increasing age individual interferon mice reversed SARS-COV-2 infection severe COVID-19 severe disease severity of COVID-19 susceptibility Therapeutic treatment type I virus replication [DOI] 10.1084/jem.20220621 PMC 바로가기
Identification of the Hub Genes and the Signaling Pathways in Human iPSC-Cardiomyocytes Infected by SARS-CoV-2Article Published on 2022-12-012022-11-16 Journal: Biochemical Genetics [Category] COVID19(2023년), SARS, 유전자 메커니즘, [키워드] Analysis applied Bioinformatics analysis biological process Biomarker Brain caused component Cytoscape software database dataset DEGs differentially expressed gene direct infection down-regulated gene enrichment analysis function Gene Expression Omnibus gene expression profile Gene ontology Genes GEO GraphPad Prism software High-throughput sequencing hub genes Human Human iPSC-cardiomyocytes identification infected with SARS-CoV-2 intestine KEGG kidney Kyoto Ligand liver Lung injury mechanisms myocardial injury organ pathway Pathways PPI PPI network protein-protein interaction R software receptor Research respiratory respiratory symptom SARS-CoV-2 SARS-CoV-2. screened sequencing data signaling pathway single-stranded RNA virus statistical analysis statistically significant TNF signaling Type type I interferon up-regulated was obtained was performed website [DOI] 10.1007/s10528-022-10206-7 PMC 바로가기
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent mannerSARS-CoV-2 슈도바이러스는 Arf6 의존적 방식으로 스파이크 단백질-CD147을 통해 숙주 세포에 들어갑니다.Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 approach Arf6 blockade CD147 cells clathrin Clathrin-mediated endocytosis clinically coronavirus endocytic endocytic mechanism endocytosis evaluate feasible function host cell host cells Huh-7 cell Huh-7 cells independent independent of indicated infected Vero E6 cells Infection inhibited inhibitor knockdown Localization macropinocytosis pathway Prevent pseudovirus pseudovirus infection public health RAB5A SARS-CoV-2 SARS-CoV-2 entry SARS-COV-2 infection SARS-CoV-2 pseudovirus SARS-CoV-2 pseudovirus infection severe acute respiratory syndrome Coronavirus Spike protein spike protein. Spread the SARS-CoV-2 variant Vero E6 VERO E6 cells viral infection weakened [DOI] 10.1080/22221751.2022.2059403 PMC 바로가기 [Article Type] Article
Epigenetic perspectives of COVID-19: Virus infection to disease progression and therapeutic controlResearch article Published on 2022-12-012022-10-05 Journal: Biochimica et biophysica acta. Molecular basis of [Category] COVID19(2023년), SARS, 변종, 신약개발, 유전자 메커니즘, 치료제, [키워드] ACE2 analysed antagonistic autophagy caused Cell cellular metabolism cellular processe Course COVID-19 death Disease progression enzyme Epigenetic epigenetics example expression profile function genes encoding Genome Host host cell IL-6 Infection investigated Laboratory Lipid mechanism membrane metabolic activity metabolic pathway methionine pathogen invasion patients Perspective progression rDNA Regulation replication mechanism ribosome S-adenosylmethionine SARS-CoV-2 sera social isolation the disease the patient therapeutic therapy tissue viral loads virus virus particle virus replication [DOI] 10.1016/j.bbadis.2022.166527 [Article Type] Research article
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Modeling studies on the role of vitamins B1 (thiamin), B3 (nicotinamide), B6 (pyridoxamine), and caffeine as potential leads for the drug design against COVID-19Article Published on 2022-11-072022-11-15 Journal: Journal of molecular modeling [Category] SARS, 신약개발, 치료제, [키워드] ACE-2 adopted Antiviral antiviral activity applied approach binding pocket binding site caffeine Cell Characteristics chemical property Compound COVID-19 COVID-19 pandemic docking domain dosage drug design effective evaluate function impair Interaction Invasion lack mechanism modeling molecular molecular dynamic simulations Neutral nicotinamide potential mechanism Protein pyridoxamine Safe SARS-CoV-2 selected Side effects Structural analysis Structure the SARS-CoV-2 the Spike thiamin Toxicity Vitamin Vitamin B. [DOI] 10.1007/s00894-022-05356-9 PMC 바로가기
Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of actionArticle Published on 2022-11-012022-11-16 Journal: Genes & genomics [Category] SARS, 유전자 메커니즘, [키워드] acute respiratory syndrome base Base sequence Cloverleaf model of tRNA complementary coronavirus Evidence function genetic component Genome homology human gene intron involved mechanism of action Messenger RNA molecular Mutation mutation. produced question robust SARS-CoV SARS-CoV-2 sequence therapeutic agents viruses [DOI] 10.1007/s13258-022-01299-w PMC 바로가기
Utility of NO and H2S donating platforms in managing COVID-19: Rationale and promiseReview article Published on 2022-11-012022-10-05 Journal: Nitric oxide : biology and chemistry [Category] SARS, 바이오마커, 변종, 치료제, [키워드] addition anti-inflammatory property Antiviral antiviral action antiviral therapies changes Complication COVID-19 COVID-19 pandemic current Cytokine storm death direct infection endothelial damage Endothelium Evidence function host cell Hydrogen sulfide Hyperinflammatory Infection Inflammation iNOS limit nitric oxide occur platform Protective pulmonary damage rationale reduce Respiratory failure Respiratory system resulting SARS-CoV-2 signaling molecule supportive therapy therapeutic approaches thrombosis Treatment Vascular vasculature viral infection viral infections [DOI] 10.1016/j.niox.2022.08.003 [Article Type] Review article
Neutrophil Extracellular Traps, Local IL-8 Expression, and Cytotoxic T-Lymphocyte Response in the Lungs of Patients With Fatal COVID-19Article Published on 2022-11-012022-11-16 Journal: Chest [Category] COVID19(2023년), SARS, 치료기술, [키워드] Analysis analyzed association Bacteria bronchiolar CD8+ T-cell chemokine correlated COVID-19 CXCL8 Cytokines cytotoxic death Defense Diseases eight exploratory expression Extracellular fatal COVID-19 function heterogeneity IL-8 immune response immunohistochemistry infiltration Inflammation Inflammatory inherent leukocyte liver tissues Local lung Lungs mechanism Messenger RNA mRNA mRNA levels multiplexed immunofluorescence NET NETosis NETs neutrophil Neutrophil extracellular trap Neutrophil extracellular traps Neutrophils neutrophils. no correlation pathogenic Patient polymerase chain pulmonary thrombi quantified Respiratory failure response SARS-CoV-2 severe COVID-19 shown T-lymphocyte the SARS-CoV-2 tissue tissue damage tissue viral load validation cohorts viral loads [DOI] 10.1016/j.chest.2022.06.007 PMC 바로가기